Publications

ORCID: 0000-0003-2745-2843

Journal Papers                                                                                         

co-first authors

Li, J.; Jo, M. H.; Yan, J.; Hall, T.; Lee, J.; López-Sánchez, U.; Yan, S.; Ha, T.; Springer, T. A. Ligand Binding Initiates Single-Molecule Integrin Conformational Activation. Cell 2024. https://doi.org/10.1016/j.cell.2024.04.049.

Jo, M. H.; Meneses, P.; Yang, O.; Carcamo, C. C.; Pangeni, S.; Ha, T. Determination of Single-Molecule Loading Rate during Mechanotransduction in Cell Adhesion. Science 2024. https://doi.org/10.1126/science.adk6921.
*Highlighted in Nature Methods: "Probing single-molecule loading rates" https://doi.org/10.1038/s41592-024-02290-x

Min, K.-W.; Jo, M. H.; Song, M.; Lee, J. W.; Shim, M. J.; Kim, K.; Park, H. B.; Ha, S.; Mun, H.; Polash, A.; Hafner, M.; Cho, J.-H.; Kim, D.; Jeong, J.-H.; Ko, S.; Hohng, S.; Kang, S.-U.; Yoon, J.-H. Mature MicroRNA-Binding Protein QKI Promotes MicroRNA-Mediated Gene Silencing. RNA Biology 2024. https://doi.org/10.1080/15476286.2024.2314846.

Jo, M. H.; Li, J.; Jaumouillé, V.; Hao, Y.; Coppola, J.; Yan, J.; Waterman, C. M.; Springer, T. A.; Ha, T. Single-Molecule Characterization of Subtype-Specific Β1 Integrin Mechanics. Nat Commun 2022. https://doi.org/10.1038/s41467-022-35173-w.

Morikis, V. A.; Chen, S. J.; Madigan, J.; Jo, M. H.; Werba, L. C.; Ha, T.; Simon, S. I. Β2-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response. Cells 2022. https://doi.org/10.3390/cells11182822.

Pittman, M.; Iu, E.; Li, K.; Wang, M.; Chen, J.; Taneja, N.; Jo, M. H.; Park, S.; Jung, W.; Liang, L.; Barman, I.; Ha, T.; Gaitanaros, S.; Liu, J.; Burnette, D.; Plotnikov, S.; Chen, Y. Membrane Ruffling Is a Mechanosensor of Extracellular Fluid Viscosity. Nature Physics 2022. https://doi.org/10.1038/s41567-022-01676-y.

Poyton, M. F.; Feng, X. A.; Ranjan, A.; Lei, Q.; Wang, F.; Zarb, J. S.; Louder, R. K.; Park, G.; Jo, M. H.; Ye, J.; Liu, S.; Ha, T.; Wu, C. Coordinated DNA and Histone Dynamics Drive Accurate Histone H2A.Z Exchange. Science Advances 2022. https://doi.org/10.1126/sciadv.abj5509.

Jo, M. H.; Kim, B. C.; Sung, K.; Panettieri, R. A.; An, S. S.; Liu, J.; Ha, T. Molecular Nanomechanical Mapping of Histamine-Induced Smooth Muscle Cell Contraction and Shortening. ACS Nano 2021. https://doi.org/10.1021/acsnano.1c01782.

Wang, Y.; Mallon, J.; Wang, H.; Singh, D.; Hyun Jo, M.; Hua, B.; Bailey, S.; Ha, T. Real-Time Observation of Cas9 Postcatalytic Domain Motions. Proceedings of the National Academy of Sciences 2021. https://doi.org/10.1073/pnas.2010650118.

Park, S.; Shi, Y.; Kim, B. C.; Jo, M. H.; Cruz, L. O. L. O.; Gou, Z.; Ha, T.; Lu, L.-F. F.; Reich, D. H.; Chen, Y. Force-Dependent Trans-Endocytosis by Breast Cancer Cells Depletes Costimulatory Receptor CD80 and Attenuates T Cell Activation. Biosensors and Bioelectronics 2020. https://doi.org/10.1016/j.bios.2020.112389.

Jo, M. H.; Cottle, W. T.; Ha, T. Real-Time Measurement of Molecular Tension during Cell Adhesion and Migration Using Multiplexed Differential Analysis of Tension Gauge Tethers. ACS Biomaterials Science & Engineering 2019. https://doi.org/10.1021/acsbiomaterials.8b01216.

Min, K.-W. W.; Jo, M. H.; Shin, S.; Davila, S.; Zealy, R. W.; Kang, S. I.; Lloyd, L. T.; Hohng, S.; Yoon, J.-H. H. AUF1 Facilitates MicroRNA-Mediated Gene Silencing. Nucleic Acids Research 2017. https://doi.org/10.1093/nar/gkx149.

Kwon, S. C.; Nguyen, T. A.; Choi, Y. G.; Jo, M. H.; Hohng, S.; Kim, V. N.; Woo, J. S. Structure of Human DROSHA. Cell 2016. https://doi.org/10.1016/j.cell.2015.12.019.

Jo, M. H.; Shin, S.; Jung, S. R.; Kim, E.; Song, J. J.; Hohng, S. Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs. Molecular Cell 2015. https://doi.org/10.1016/j.molcel.2015.04.027.

Yoon, J. H.; Jo, M. H.; White, E. J. F. F.; De, S.; Hafner, M.; Zucconi, B. E.; Abdelmohsen, K.; Martindale, J. L.; Yang, X.; Wood, W. H.; Shin, Y. M.; Song, J. J.; Tuschl, T.; Becker, K. G.; Wilson, G. M.; Hohng, S.; Gorospe, M. AUF1 Promotes Let-7b Loading on Argonaute 2. Genes and Development 2015. https://doi.org/10.1101/gad.263749.115.

Nguyen, T. A.; Jo, M. H.; Choi, Y. G.; Park, J.; Kwon, S. C.; Hohng, S.; Kim, V. N.; Woo, J. S. Functional Anatomy of the Human Microprocessor. Cell 2015. https://doi.org/10.1016/j.cell.2015.05.010.

Hyun, S.; Han, A.; Jo, M. H.; Hohng, S.; Yu, J. Dicer Nuclease-Promoted Production of Let7a-1 MicroRNA Is Enhanced in the Presence of Tryptophan-Containing Amphiphilic Peptides. ChemBioChem 2014. https://doi.org/10.1002/cbic.201402126.

Hohng, S.; Lee, S.; Lee, J.; Jo, M. H. Maximizing Information Content of Single-Molecule FRET Experiments: Multi-Color FRET and FRET Combined with Force or Torque. Chemical Society Reviews 2014, pp 1007–1013. https://doi.org/10.1039/c3cs60184f.

Peisley, A.; Jo, M. H.; Lin, C.; Wu, B.; Orme-Johnson, M.; Walz, T.; Hohng, S.; Hur, S. Kinetic Mechanism for Viral DsRNA Length Discrimination by MDA5 Filaments. Proc Natl Acad Sci U S A 2012. https://doi.org/10.1073/pnas.1208618109.